Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature

@article{Xu2012HighlyED,
  title={Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature},
  author={Huansheng Xu and B. Alexander Yi and Hao Wu and Christoph Bock and Hongcang Gu and Kathy O Lui and Joo-Hye C. Park and Ying Shao and Alyssa K Riley and Ibrahim John Domian and Erding Hu and Robert Willette and John J. Lepore and Alexander Meissner and Zhong Wang and Kenneth R. Chien},
  journal={Cell Research},
  year={2012},
  volume={22},
  pages={142-154}
}
Cardiomyocytes derived from pluripotent stem cells can be applied in drug testing, disease modeling and cell-based therapy. However, without procardiogenic growth factors, the efficiency of cardiomyogenesis from pluripotent stem cells is usually low and the resulting cardiomyocyte population is heterogeneous. Here, we demonstrate that induced pluripotent stem cells (iPSCs) can be derived from murine ventricular myocytes (VMs), and consistent with other reports of iPSCs derived from various… CONTINUE READING
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