Highly efficient base excision repair (BER) in human and rat male germ cells.

@article{Olsen2001HighlyEB,
  title={Highly efficient base excision repair (BER) in human and rat male germ cells.},
  author={A. K. Olsen and H Bj\ortuft and Richard Wiger and J\orn A Holme and Erling Seeberg and Magnar Bj\or{\aa}s and Gunnar Brunborg},
  journal={Nucleic acids research},
  year={2001},
  volume={29 8},
  pages={1781-90}
}
The quality of germ cell DNA is critical for the fate of the offspring, yet there is limited knowledge of the DNA repair capabilities of such cells. One of the main DNA repair pathways is base excision repair (BER) which is initiated by DNA glycosylases that excise damaged bases, followed by incision of the generated abasic (AP) sites. We have studied human and rat methylpurine-DNA glycosylase (MPG), uracil-DNA glycosylase (UNG), and the major AP endonuclease (HAP1/APEX) in male germ cells… CONTINUE READING