Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells.

Abstract

We developed a method for the efficient generation of functional dopaminergic (DA) neurons from human embryonic stem cells (hESCs) on a large scale. The most unique feature of this method is the generation of homogeneous spherical neural masses (SNMs) from the hESC-derived neural precursors. These SNMs provide several advantages: (i) they can be passaged… (More)
DOI: 10.1073/pnas.0712359105

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@article{Cho2008HighlyEA, title={Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells.}, author={Myung Soo Cho and Young-eun Lee and Ji Young Kim and Seungsoo Chung and Yoon Hee Cho and Dae-Sung Kim and Sang-Moon Kang and Haksup Lee and Myung-Hwa Kim and Jeong-Hoon Kim and Joong Woo Leem and Sun Kyung Oh and Young Min Choi and D. Hwang and Jin Woo Chang and Dong-wook Kim}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2008}, volume={105 9}, pages={3392-7} }