Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.

@article{Gantz2015HighlyEC,
  title={Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.},
  author={Valentino Matteo Gantz and Nijole Jasinskiene and Olga Tatarenkova and Aniko Fazekas and Vanessa M Macias and Ethan Bier and Anthony A. James},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 49},
  pages={E6736-43}
}
Genetic engineering technologies can be used both to create transgenic mosquitoes carrying antipathogen effector genes targeting human malaria parasites and to generate gene-drive systems capable of introgressing the genes throughout wild vector populations. We developed a highly effective autonomous Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9)-mediated gene-drive system in the Asian malaria vector Anopheles stephensi, adapted from the mutagenic… CONTINUE READING
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