Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance?

@article{Lerang1997HighlyET,
  title={Highly effective twice-daily triple therapies for Helicobacter pylori infection and peptic ulcer disease: does in vitro metronidazole resistance have any clinical relevance?},
  author={Frode Lerang and Bjorn A Moum and Judith Haug and P Tol{\aa}s and O Breder and E J Aubert and Ole H\oie and T S\oberg and B O Flaaten and Per G Farup and Trygve Berge},
  journal={The American journal of gastroenterology},
  year={1997},
  volume={92 2},
  pages={248-53}
}
OBJECTIVES To compare cure rates of Helicobacter pylori (H. pylori) infection, ulcer healing, and side effects of three simplified regimens of triple therapy in patients with peptic ulcer disease. METHODS Two hundred thirty-one patients were prospectively randomized to receive either regimen OAM (omeprazole 20 mg b.i.d., amoxicillin 750 mg b.i.d., and metronidazole 400 g b.i.d.), OCM (omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d., and metronidazole 400 mg b.i.d.), or BCM (bismuth… CONTINUE READING

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