Highly discriminating photorelease of anticancer drugs based on hypoxia activatable phototrigger conjugated chitosan nanoparticles.

@article{Lin2013HighlyDP,
  title={Highly discriminating photorelease of anticancer drugs based on hypoxia activatable phototrigger conjugated chitosan nanoparticles.},
  author={Qiuning Lin and Chunyan Bao and Yunlong Yang and Qiannan Liang and Dasheng Zhang and Shuiyu Cheng and Linyong Zhu},
  journal={Advanced materials},
  year={2013},
  volume={25 14},
  pages={1981-6}
}
An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a… CONTINUE READING