Highly discordant T cell responses in individuals with recent exposure to household tuberculosis.

@article{Hesseling2009HighlyDT,
  title={Highly discordant T cell responses in individuals with recent exposure to household tuberculosis.},
  author={Anneke Catharina Hesseling and Anna Maria Mandalakas and H. Lester Kirchner and Novel N Chegou and Ben Marais and Kim E. Stanley and Xaiobei Zhu and Gillian F. Black and Nulda Beyers and Gerhard Walzl},
  journal={Thorax},
  year={2009},
  volume={64 10},
  pages={
          840-6
        }
}
BACKGROUND There are limited data comparing interferon-gamma release assays (IGRAs) for the detection of Mycobacterium tuberculosis infection in highly endemic settings. METHODS A cross-sectional household contact study was conducted to measure the agreement of two IGRAs in relation to the tuberculin skin test (TST) to detect M tuberculosis infection and to assess the influence of M tuberculosis exposure and age. RESULTS In 82 individuals in household contact, 93% of children and 42% of… CONTINUE READING

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