Highly cooperative homodimerization is a conserved property of neural POU proteins.

@article{Rhee1998HighlyCH,
  title={Highly cooperative homodimerization is a conserved property of neural POU proteins.},
  author={Jerry M. Rhee and Carol A Gruber and Tammy B Brodie and May Trieu and Eric E. Turner},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 51},
  pages={
          34196-205
        }
}
POU-domain proteins have been shown to play important roles in the development of the nervous, endocrine, and immune systems. However, the distinctive DNA recognition properties of the six major POU subclasses have not been well defined. Here, we have used random oligonucleotide selection and competitive binding assays to determine the optimal DNA recognition elements for the POU-III and POU-VI protein classes, represented by Brn-2 and Brn-5, respectively. The optimal Brn-5 consensus binding… CONTINUE READING
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