Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

@article{Koch1988HighlyCF,
  title={Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions},
  author={K E Koch and Lubert Stryer},
  journal={Nature},
  year={1988},
  volume={334},
  pages={64-66}
}
Visual excitation in retinal rod cells is mediated by a cascade that leads to the amplified hydrolysis of cyclic GMP (cGMP) and the consequent closure of cGMP-activated cation-specific channels in the plasma membrane1–3. Recovery of the dark state requires the resynthesis of cGMP, which is catalysed by guanylate cyclase, an axoneme-associated enzyme4–6. The lowering of the cytosolic calcium concentration (Cai) following illumination7–10 is thought to be important in stimulating cyclase… CONTINUE READING
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