Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters.

@article{Lee2006HighlyCS,
  title={Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters.},
  author={Alison Ping Lee and Esther G L Koh and A. A. O. Tay and S. Brenner and Byrappa Venkatesh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 18},
  pages={6994-9}
}
Hox genes in vertebrates are clustered, and the organization of the clusters has been highly conserved during evolution. The conservation of Hox clusters has been attributed to enhancers located within and outside the Hox clusters that are essential for the coordinated "temporal" and "spatial" expression patterns of Hox genes in developing embryos. To identify evolutionarily conserved regulatory elements within and outside the Hox clusters, we obtained contiguous sequences for the conserved… CONTINUE READING

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