Highly conserved structural properties of the C-terminal tail of HIV-1 gp41 protein despite substantial sequence variation among diverse clades: implications for functions in viral replication.

@article{Steckbeck2011HighlyCS,
  title={Highly conserved structural properties of the C-terminal tail of HIV-1 gp41 protein despite substantial sequence variation among diverse clades: implications for functions in viral replication.},
  author={Jonathan D. Steckbeck and Jodi K. Craigo and Christopher O. Barnes and Ronald C. Montelaro},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 31},
  pages={27156-66}
}
Although the HIV-1 Env gp120 and gp41 ectodomain have been extensively characterized in terms of structure and function, similar characterizations of the C-terminal tail (CTT) of HIV gp41 remain relatively limited and contradictory. The current study was designed to examine in detail CTT sequence conservation relative to gp120 and the gp41 ectodomain and to examine the conservation of predicted physicochemical and structural properties across a number of divergent HIV clades and groups. Results… CONTINUE READING

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