Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

@article{Wiltfang2002HighlyCA,
  title={Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.},
  author={Jens Wiltfang and Hermann Esselmann and Mirko Bibl and Alexander Smirnov and Markus Otto and Sabine Paul and Bernhard M. W. Schmidt and H. Klafki and Manuel Maler and Thomas Dyrks and M. Bienert and Michael Beyermann and Eckart Ruether and Johannes Kornhuber},
  journal={Journal of neurochemistry},
  year={2002},
  volume={81 3},
  pages={481-96}
}
Human lumbar CSF patterns of Abeta peptides were analysed by urea-based beta-amyloid sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Abeta-SDS-PAGE/immunoblot). A highly conserved pattern of carboxyterminally truncated Abeta1-37/38/39 was found in addition to Abeta1-40 and Abeta1-42. Remarkably, Abeta1-38 was present at a higher concentration than Abeta1-42, being the second prominent Abeta peptide species in CSF. Patients with Alzheimer's disease (AD, n = 12… CONTINUE READING

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