Highly branched HK peptides are effective carriers of siRNA.

@article{Leng2005HighlyBH,
  title={Highly branched HK peptides are effective carriers of siRNA.},
  author={Qixin Leng and Puthupparampil V. Scaria and Jingsong Zhu and Jr. Nicholas P. Ambulos and Patricia Campbell and A James Mixson},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 7},
  pages={
          977-86
        }
}
BACKGROUND Both viral and nonviral carriers have been used to carry small interfering RNA molecules (siRNA) to their cytosolic mRNA target. To date, few peptide carriers have been developed that have proved effective for siRNA delivery. Our previous branched carriers composed of histidine and lysine were useful for transfection of plasmids. In this study, we determined if these and more highly branched HK polymers were effective carriers of siRNA. METHODS Several branched polymers were… CONTINUE READING

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