Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection

@article{Drifka2016HighlyAS,
  title={Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection},
  author={Cole R. Drifka and Agnes G. Loeffler and Kara Mathewson and Adib Keikhosravi and Jens Eickhoff and Yuming Liu and Sharon M. Weber and Weiyuan John Kao and Kevin W. Eliceiri},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={76197 - 76213}
}
  • Cole R. Drifka, Agnes G. Loeffler, +6 authors Kevin W. Eliceiri
  • Published in Oncotarget 2016
  • Medicine
  • Risk factors for pancreatic ductal adenocarcinoma (PDAC) progression after surgery are unclear, and additional prognostic factors are needed to inform treatment regimens and therapeutic targets. PDAC is characterized by advanced sclerosis of the extracellular matrix, and interactions between cancer cells, fibrillar collagen, and other stromal components play an integral role in progression. Changes in stromal collagen alignment have been shown to modulate cancer cell behavior and have important… CONTINUE READING

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