Highly active antiretroviral therapy results in a decrease in CD8+ T cell activation and preferential reconstitution of the peripheral CD4+ T cell population with memory rather than naive cells.

@article{Evans1998HighlyAA,
  title={Highly active antiretroviral therapy results in a decrease in CD8+ T cell activation and preferential reconstitution of the peripheral CD4+ T cell population with memory rather than naive cells.},
  author={Thomas G. Evans and William Bonnez and Harold Soucier and Trinita Fitzgerald and David C. Gibbons and Richard C Reichman},
  journal={Antiviral research},
  year={1998},
  volume={39 3},
  pages={163-73}
}
OBJECTIVE Highly active antiretroviral therapy (HAART) can produce marked increases in peripheral blood CD4+ T cells and decreases in HIV plasma RNA copy numbers. However, it is not clear whether these absolute changes will be accompanied by a recovery in the known naive CD4+ T cell depletion or a decrease in the marked CD8+ T cell activation. DESIGN Twenty-nine patients were enrolled in studies of either nucleoside therapy alone or nucleoside therapy combined with a protease inhibitor… CONTINUE READING

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