Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection.

@article{Cossarizza2004HighlyAA,
  title={Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection.},
  author={Andrea Cossarizza and Fabrizio Poccia and Chiara Agrati and Gianpiero D'offizi and Roberto Bugarini and Marcello Pinti and Vanni Borghi and Cristina Mussini and R. Esposito and Giuseppe Ippolito and Pasquale Narciso},
  journal={Journal of acquired immune deficiency syndromes},
  year={2004},
  volume={35 3},
  pages={213-22}
}
In drug-naive HIV+ patients, we analyzed the effects of highly active antiretroviral therapy (HAART) on the reconstitution of the T-cell receptor (TCR) repertoire. We followed 2 groups of patients for 1 year: 18 individuals who experienced acute HIV infection and 24 patients who had HIV infection for many years but never took HAART. They were compared with 10 healthy controls who were longitudinally analyzed for the same period. We performed cytofluorometric analysis of the Vbeta TCR repertoire… CONTINUE READING

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