Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.

@article{Price2007HighlyAT,
  title={Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.},
  author={Nathan D. Price and Jonathan A Trent and A El-naggar and David Cogdell and Ellen B. Taylor and Kelly K. Hunt and Raphael E Pollock and Leroy Hood and Ilya Shmulevich and Wei Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 9},
  pages={3414-9}
}
Gastrointestinal stromal tumor (GIST) has emerged as a clinically distinct type of sarcoma with frequent overexpression and mutation of the c-Kit oncogene and a favorable response to imatinib mesylate [also known as STI571 (Gleevec)] therapy. However, a significant diagnostic challenge remains in the differentiation of GIST from leiomyosarcomas (LMSs). To improve on the diagnostic evaluation and to complement the immunohistochemical evaluation of these tumors, we performed a whole-genome gene… CONTINUE READING

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