Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling.

@article{Tiss2010HighlyAD,
  title={Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling.},
  author={Ali Tiss and John F Timms and Celia J. Smith and Dmitry Devetyarov and Aleksandra Gentry-Maharaj and Stephane Camuzeaux and Brian Burford and Ilia Nouretdinov and Jeremy W. Ford and Z Luo and Ian Jacobs and Usha Menon and Alex Gammerman and R Cramer},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2010},
  volume={20 9},
  pages={
          1518-24
        }
}
OBJECTIVES Our objective was to test the performance of CA125 in classifying serum samples from a cohort of malignant and benign ovarian cancers and age-matched healthy controls and to assess whether combining information from matrix-assisted laser desorption/ionization (MALDI) time-of-flight profiling could improve diagnostic performance. MATERIALS AND METHODS Serum samples from women with ovarian neoplasms and healthy volunteers were subjected to CA125 assay and MALDI time-of-flight mass… CONTINUE READING

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