Highly Transient Molecular Interactions Underlie the Stability of Kinetochore-Microtubule Attachment During Cell Division.

@article{Zaytsev2013HighlyTM,
  title={Highly Transient Molecular Interactions Underlie the Stability of Kinetochore-Microtubule Attachment During Cell Division.},
  author={Anatoly V. Zaytsev and Fazoil I. Ataullakhanov and Ekaterina L Grishchuk},
  journal={Cellular and molecular bioengineering},
  year={2013},
  volume={6 4}
}
Chromosome segregation during mitosis is mediated by spindle microtubules that attach to chromosomal kinetochores with strong yet labile links. The exact molecular composition of the kinetochore-microtubule interface is not known but microtubules are thought to bind to kinetochores via the specialized microtubule-binding sites, which contain multiple microtubule-binding proteins. During prometaphase the lifetime of microtubule attachments is short but in metaphase it increases 3-fold… CONTINUE READING
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