Highly Stable and Luminescent Oxygen Nanosensor Based on Ruthenium-Containing Metallopolymer for Real-Time Imaging of Intracellular Oxygenation.

@article{Zhou2019HighlySA,
  title={Highly Stable and Luminescent Oxygen Nanosensor Based on Ruthenium-Containing Metallopolymer for Real-Time Imaging of Intracellular Oxygenation.},
  author={Chao Zhou and Wu-Xing Zhao and Fang-tian You and Zhaoxin Geng and Hong‐shang Peng},
  journal={ACS sensors},
  year={2019},
  volume={4 4},
  pages={
          984-991
        }
}
Metal complex-based luminescent oxygen nanosensors have been intensively studied for biomedical applications. In terms of monitoring dynamics of intracellular oxygen, however, high-quality nanosensors are still badly needed, because of stringent requirements on stability, biocompatibility and luminescence intensity, aside from oxygen sensitivity. In this paper, we reported a type of highly luminescent and stable oxygen nanosensors prepared from metallopolymer. First, a novel ruthenium(II… 
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References

SHOWING 1-10 OF 35 REFERENCES
Biocompatible fluorescent core–shell nanoparticles for ratiometric oxygen sensing
TLDR
The resultant core–shell NPs with functional groups exhibit low cytotoxic effects as well as effortless cellular uptake, indicating targeted intracellular oxygen sensing is very promising using the oxygen nanosensors.
Luminescent Ru(bpy)32+-doped silica nanoparticles for imaging of intracellular temperature
AbstractSilica nanoparticles doped with the luminescent temperature probe Ru(bpy)32+ were prepared by a modified Stöber method and are shown to enable optical sensing of intracellular temperatures.
Intracellular and in vivo oxygen sensing using phosphorescent Ir(III) complexes with a modified acetylacetonato ligand.
TLDR
It is demonstrated that BTPDM1 can be used as a small molecular probe for measuring intracellular O2 levels in both cultured cells and specific tissues and organs.
A Phosphorescent Nanoparticle‐Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities
TLDR
A new cell‐penetrating phosphorescent nanosensor material called MM2 probe, which combines high brightness, photo‐ and chemical stability, low toxicity, and ease of fabrication and use, is presented.
A Hydrogen‐Bonded‐Supramolecular‐Polymer‐Based Nanoprobe for Ratiometric Oxygen Sensing in Living Cells
The first example of a ratiometric optical oxygen nanoprobe based on a hydrogen‐bonded supramolecular polymer has been reported. The supramolecular polymer based nanoprobe (SPNP) is prepared from the
Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles.
TLDR
The NP probe was seen to generate stable and reproducible signals in different types of mammalian cells and robust responses to their metabolic stimulation, thus allowing accurate quantitative analysis.
Dendritic phosphorescent probes for oxygen imaging in biological systems.
TLDR
A general approach to the construction of phosphorescent nanosensors with tunable spectral characteristics, variable degrees of quenching, and a high selectivity for oxygen is described.
Ruthenium complexes with hydrophobic ligands that are key factors for the optical imaging of physiological hypoxia.
TLDR
Among the complexes synthesized in this study, a pyrene chromophore-linked ruthenium complex, Ru-Py, exhibited optimal properties for the imaging of hypoxia and could clearly discriminate between hypoxic and aerobic cells by monitoring the phosphorescence emission.
Compact Conjugated Polymer Dots with Covalently Incorporated Metalloporphyrins for Hypoxia Bioimaging
TLDR
Hypoxia imaging in vitro and in vivo was realized, and a clear increase in brightness was observed under hypoxia conditions and in the tumor area, which is beneficial to potential applications in cancer diagnosis.
...
...