Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay

  title={Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay},
  author={Tobias Klamp and Marta Camps and Benjamin Nieto and Francesc Guasch and Rohan T Ranasinghe and Jens Wiedemann and Zdenek Petrasek and Petra Schwille and David Klenerman and Markus Sauer},
  booktitle={Scientific reports},
There is an urgent need for rapid and highly sensitive detection of pathogen-derived DNA in a point-of-care (POC) device for diagnostics in hospitals and clinics. This device needs to work in a 'sample-in-result-out' mode with minimum number of steps so that it can be completely integrated into a cheap and simple instrument. We have developed a method that directly detects unamplified DNA, and demonstrate its sensitivity on realistically sized 5 kbp target DNA fragments of Micrococcus luteus in… CONTINUE READING
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Direct observation of the nanoscale dynamics of membrane lipids in a living cell

  • C. Eggeling
  • Nature
  • 2009

Enhanced DNA detection based on the amplification of gold nanoparticles using quartz crystal microbalance

  • L. Nie, Y. Yang, S. Li, N. He
  • Nanotechnology 18,
  • 2007

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