Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay

@inproceedings{Klamp2013HighlyRA,
  title={Highly Rapid Amplification-Free and Quantitative DNA Imaging Assay},
  author={Tobias Klamp and Marta Camps and Benjamin Nieto and Francesc Guasch and Rohan T Ranasinghe and Jens Wiedemann and Zdenek Petrasek and Petra Schwille and David Klenerman and Markus Sauer},
  booktitle={Scientific reports},
  year={2013}
}
There is an urgent need for rapid and highly sensitive detection of pathogen-derived DNA in a point-of-care (POC) device for diagnostics in hospitals and clinics. This device needs to work in a 'sample-in-result-out' mode with minimum number of steps so that it can be completely integrated into a cheap and simple instrument. We have developed a method that directly detects unamplified DNA, and demonstrate its sensitivity on realistically sized 5 kbp target DNA fragments of Micrococcus luteus in… CONTINUE READING
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