Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORa

  title={Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORa},
  author={Judith Friesenhagen and Dorothee Viemann and Yvonne B{\"o}rgeling and Mirco Schmolke and Christoph Spiekermann and Susanne Kirschnek and Stephan Ludwig and Johannes Roth},
  journal={Journal of Innate Immunity},
  pages={505 - 518}
Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstrate a reduced immune response of human monocytes to HPAIV H5N1 compared to human influenza A viruses. In bioinformatic analyses we could reveal a potential role of the Rar-related… 

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