Highly Pathogenic Avian Influenza Virus H5N1 Infects Alveolar Macrophages without Virus Production or Excessive TNF-Alpha Induction

@inproceedings{Riel2011HighlyPA,
  title={Highly Pathogenic Avian Influenza Virus H5N1 Infects Alveolar Macrophages without Virus Production or Excessive TNF-Alpha Induction},
  author={Debby van Riel and Lonneke M. E. Leijten and M van der Eerden and Henk C. Hoogsteden and Leonie A. Boven and Bart M. Lambrecht and Albert D M E Osterhaus and Thijs Kuiken},
  booktitle={PLoS pathogens},
  year={2011}
}
Highly pathogenic avian influenza virus (HPAIV) of the subtype H5N1 causes severe, often fatal pneumonia in humans. The pathogenesis of HPAIV H5N1 infection is not completely understood, although the alveolar macrophage (AM) is thought to play an important role. HPAIV H5N1 infection of macrophages cultured from monocytes leads to high percentages of infection accompanied by virus production and an excessive pro-inflammatory immune response. However, macrophages cultured from monocytes are… CONTINUE READING