Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits

  title={Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits},
  author={Sen Song and P Jesper Sj{\"o}str{\"o}m and Markus Reigl and Sacha Nelson and Dmitri B. Chklovskii},
  journal={PLoS Biology},
  pages={1 - 340}
How different is local cortical circuitry from a random network? To answer this question, we probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex. Analysis of this dataset revealed several nonrandom features in synaptic connectivity. We confirmed previous reports that bidirectional connections are more common than expected in a random network. We found that several highly clustered three-neuron… CONTINUE READING
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A network of tufted layer five pyramidal neurons

  • H Markram, J Lübke, M Frotscher, B Sakmann
  • Cereb Cortex
  • 1997
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