Highly Expressed and Slowly Evolving Proteins Share Compositional Properties with Thermophilic Proteins

@inproceedings{Cherry2010HighlyEA,
  title={Highly Expressed and Slowly Evolving Proteins Share Compositional Properties with Thermophilic Proteins},
  author={Joshua L. Cherry},
  booktitle={Molecular biology and evolution},
  year={2010}
}
The sequences of proteins encoded by a genome evolve at different rates. A correlate of a protein's evolutionary rate is its expression level: highly expressed proteins tend to evolve slowly. Some explanations of rate variation and the correlation between rate and expression predict that more slowly evolving and more highly expressed proteins have more favorable equilibrium constants for folding. Proteins from thermophiles generally have more stable folds than proteins from mesophiles, and it… CONTINUE READING

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