Highlights of glucosamine-6P synthase catalysis.

  title={Highlights of glucosamine-6P synthase catalysis.},
  author={Philippe Durand and B{\'e}atrice Golinelli-Pimpaneau and St{\'e}phane Mouilleron and Bernard Badet and Marie-Ange Badet-Denisot},
  journal={Archives of biochemistry and biophysics},
  volume={474 2},
L-Glutamine:d-fructose-6-phosphate amidotransferase, also known as glucosamine-6-phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading to the formation of uridine 5'-diphospho-N-acetyl-d-glucosamine (UDP-GlcNAc), is a key point in the metabolic control of the biosynthesis of amino sugar-containing macromolecules. The molecular mechanism of the reaction catalyzed by GlcN6P synthase is complex and involves amide bond cleavage followed by ammonia channeling and… CONTINUE READING
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