Higher urine desmosine levels are associated with mortality in patients with acute lung injury.

@article{McClintock2006HigherUD,
  title={Higher urine desmosine levels are associated with mortality in patients with acute lung injury.},
  author={Dana E McClintock and Barry C. Starcher and Mark David Eisner and Boyd Taylor Thompson and Doug L Hayden and Gwynne D Church and Michael A. Matthay},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 4},
  pages={L566-71}
}
Desmosine is a stable breakdown product of elastin that can be reliably measured in urine samples. We tested the hypothesis that higher baseline urine desmosine would be associated with higher mortality in 579 of 861 patients included in the recent Acute Respiratory Distress Syndrome Network trial of lower tidal volume ventilation (1). We also correlated urine desmosine levels with indexes of disease severity. Finally, we assessed whether urine desmosine was lower in patients who received lower… CONTINUE READING

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