Higher susceptibility of newborn than young rats to 3-methylphenol.

  title={Higher susceptibility of newborn than young rats to 3-methylphenol.},
  author={Mutsuko Koizumi and Atsushi Noda and Yoshihiko Ito and Masatoshi Furukawa and Sakiko Fujii and Eiichi Kamata and Makoto Ema and Ryuichi Hasegawa},
  journal={The Journal of toxicological sciences},
  volume={28 2},
To determine susceptibility of infants to 3-methylphenol, a repeated dose toxicity study was conducted with oral administration to newborn and young rats. In an 18-day newborn study from postnatal days 4 to 21 at doses of 30, 100 and 300 mg/kg/day, various clinical signs including deep respiration, hypersensitivity on handling and tremors under contact stimulus, and depressed body weight gain were observed at 300 mg/kg. At 100 mg/kg, hypersensitivity and tremors were also noted in a small… CONTINUE READING
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