Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation.

@article{Zhu2010HigherSO,
  title={Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation.},
  author={Zhixiang Zhu and Quanbin Zhang and Lihong Chen and Shuang Ren and Ping-xiang Xu and Yu Tang and Dali Luo},
  journal={Thrombosis research},
  year={2010},
  volume={125 5},
  pages={
          419-26
        }
}
Study on antithrombotic and antiplatelet activities of low molecular weight fucoidan from Laminaria japonica
TLDR
Highly sulfated fucoidan LF2 with Mw 3900 seemed to be a more suitable choice for antithrombotic drug for its antithROMbotic activity accompanied with specific inhibitory activity on platelet aggregation, low anticoagulant activity and low hemorrhagic risk in vivo.
Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.
TLDR
The results suggested that dietary FD stimulated the expression of H2O2-producing enzymes in intestinal epithelial cells and released H2 O2 into the blood, which played a signalling role to increase PGI2 production and then shortened LT for thrombi.
The Antithrombotic Effects of Low Molecular Weight Fragment from Enzymatically Modified of Laminaria Japonica Polysaccharide
TLDR
LMWEP, an enzymatically modified fragment with a molecular weight of 25.8 kDa, is a potential antithrombotic candidate for treatment of thrombosis related diseases.
Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica.
Mechanism study of endothelial protection and inhibits platelet activation of low molecular weight fucoidan from Laminaria japonica
TLDR
By inhibiting platelet adhesion, LMW fucoidan played a role in anti-thrombosis and the specific mechanism of action is to inhibit the flow of extracellular Ca2+.
Algal fucoidan, unlike heparin, has thrombolytic activity in a murine arterial thrombosis model
TLDR
Algal fucoidan has both thrombolytic activity and a stimulatory effect on the thrombosynthetic activity of t-PA in a dose-dependent manner at an arterial thrombosis model.
A promising oral fucoidan-based antithrombotic nanosystem: Development, activity and safety.
TLDR
Surprisingly, oral antithrombotic profile of commercially available fucoidan, from Fucus vesiculosus, has not been previously determined, which reveals new possibilities in anticoagulant and antithROMbotic profiles offucoidan through the preparation of NpCF 1%.
Anti-Inflammatory Activity of Fucoidan Extracts In Vitro
TLDR
Fucoidan extracts from all species had significant anti-inflammatory effects, but the lowest molecular weight subfractions had maximal effects at low concentrations, which may offer insight into strategies that improve their efficacy against inflammation-related pathology.
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