Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging

@article{Reiman2010HigherST,
  title={Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging},
  author={Eric Reiman and Kewei Chen and Jessica B. S. Langbaum and Wendy Lee and Cole Reschke and Daniel Bandy and Gene E. Alexander and Richard J. Caselli},
  journal={NeuroImage},
  year={2010},
  volume={49 1},
  pages={169-76}
}
Epidemiological studies suggest that higher midlife serum total cholesterol levels are associated with an increased risk of Alzheimer's disease (AD). Using fluorodeoxyglucose positron emission tomography (PET) in the study of cognitively normal late middle-aged people, we demonstrated an association between apolipoprotein E (APOE) epsilon4 gene dose, the major genetic risk factor for late-onset AD, and lower measurements of the cerebral metabolic rate for glucose (CMRgl) in AD-affected brain… CONTINUE READING