Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

@inproceedings{Swanson2013HigherorderUO,
  title={Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence},
  author={Eric C. Swanson and Benjamin Manning and Hong Zhang and J B Lawrence},
  booktitle={The Journal of cell biology},
  year={2013}
}
Epigenetic changes to chromatin are thought to be essential to cell senescence, which is key to tumorigenesis and aging. Although many studies focus on heterochromatin gain, this work demonstrates large-scale unraveling of peri/centromeric satellites, which occurs in all models of human and mouse senescence examined. This was not seen in cancer cells, except in a benign senescent tumor in vivo. Senescence-associated distension of satellites (SADS) occurs earlier and more consistently than… CONTINUE READING

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