Higher-order structure of mammalian chromatin deduced from viscoelastometry data.

@article{Ostashevsky1999HigherorderSO,
  title={Higher-order structure of mammalian chromatin deduced from viscoelastometry data.},
  author={Joseph Ostashevsky and Brian L Reichman and Christopher S. Lange},
  journal={Journal of biomolecular structure & dynamics},
  year={1999},
  volume={17 3},
  pages={567-80}
}
The results of viscoelastometry (VE) for mammalian DNA have been puzzling because they have two orders of magnitude smaller measured viscoelastic relaxation times for mammalian chromosomes than that expected for DNA linear coils of chromosomal size. In an attempt to resolve this discrepancy, we have applied a recent model of G1 chromosome structure (J.Y. Ostashevsky, Mol Biol. Cell 9, 3031-3040, 1998) in which the 30 nm chromatin fiber of each chromosome forms a string of loop clusters… CONTINUE READING