Higher order chromatin structure at the X-inactivation center via looping DNA.

  title={Higher order chromatin structure at the X-inactivation center via looping DNA.},
  author={Chia-Lun Tsai and Rebecca K Rowntree and Dena E. Cohen and Jeannie T Lee},
  journal={Developmental biology},
  volume={319 2},
In mammals, the silencing step of the X-chromosome inactivation (XCI) process is initiated by the non-coding Xist RNA. Xist is known to be controlled by the non-coding Xite and Tsix loci, but the mechanisms by which Tsix and Xite regulate Xist are yet to be fully elucidated. Here, we examine the role of higher order chromatin structure across the 100-kb region of the mouse X-inactivation center (Xic) and map domains of specialized chromatin in vivo. By hypersensitive site mapping and chromosome… CONTINUE READING

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