Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects.

@article{Conley2013HigherMR,
  title={Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects.},
  author={Kevin E Conley and Catherine E. Amara and Sudip Bajpeyi and Sheila R. Costford and Kori Murray and Sharon A. Jubrias and Lori Arakaki and David J. Marcinek and Steven R. Smith},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 1},
  pages={
          129-36
        }
}
OBJECTIVE This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active individuals. RESEARCH DESIGN AND METHODS Chronic activity level was characterized by a physical activity questionnaire and a triaxial accelerometer as well as a maximal oxygen uptake test. The ATP and O(2) fluxes and mitochondrial coupling (ATP/O(2) or P/O) in resting muscle as well as mitochondrial capacity (ATP(max)) were determined in vivo in… CONTINUE READING
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