Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death.

@article{Boulware2011HigherLO,
  title={Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death.},
  author={David R Boulware and Katherine Huppler Hullsiek and Camille E Puronen and Adam Rupert and Jason V Baker and Martyn A French and Paul R. Bohjanen and Richard M Novak and James D. Neaton and Irini Sereti},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 11},
  pages={1637-46}
}
BACKGROUND Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV) disease despite HIV suppression. Biomarkers may identify high-risk groups. METHODS Pre-ART and 1-month samples from an initial ART trial were evaluated for biomarkers associated with AIDS events or death within 1-12 months. Case patients (n = 63) and control patients (n = 126) were 1:2 matched on baseline CD4 cell count, hepatitis status… CONTINUE READING