Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.

@article{Guo2014HigherLO,
  title={Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.},
  author={Shoudong Guo and Yonghao Yu and Nan Zhang and Yingjie Cui and Lei Zhai and Helou Li and Ying Zhang and Fuyu Li and Yujie Kan and Shu-cun Qin},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1841 6},
  pages={836-46}
}
Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 108 healthy participants were separated into three age groups, and their plasma S1P levels were analyzed by liquid chromatography tandem mass spectrometry. Results showed that the plasma S1P levels were significantly higher in women than… CONTINUE READING

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