Higher incidence of autoantibodies in X-linked chronic granulomatous disease carriers: random X-chromosome inactivation may be related to autoimmunity.

@article{MartnVilla1999HigherIO,
  title={Higher incidence of autoantibodies in X-linked chronic granulomatous disease carriers: random X-chromosome inactivation may be related to autoimmunity.},
  author={Jos{\'e} Manuel Mart{\'i}n-Villa and Alfredo Corell and Jos{\'e} Tom{\'a}s Ramos-Amador and J{\'e}sus Ruiz-Contreras and Antonio Arnaiz-Villena},
  journal={Autoimmunity},
  year={1999},
  volume={31 4},
  pages={261-4}
}
The presence of autoantibodies and autoimmune diseases was tested in all available members of five families with at least one member affected with X-linked chronic granulomatous disease. Patients and carriers relatives possess autoantibodies more frequently than non-carriers relatives (95% vs 10%, p < 1.0 x 10(-5), Fisher test). Further, a survey of the literature revealed that in X-linked immunodeficiencies with X-chromosome random inactivation, clear features of autoimmunity are observed, not… CONTINUE READING