Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort.

@article{GkraniaKlotsas2012HigherIG,
  title={Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort.},
  author={Effrossyni Gkrania-Klotsas and Claudia Langenberg and Stephen J Sharp and Robert L Luben and Kay-tee Khaw and Nicholas J Wareham},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 12},
  pages={1897-903}
}
BACKGROUND Cytomegalovirus (CMV) is associated with ischemic heart disease (IHD) among organ transplant recipients. The relationship between the levels of antibody for CMV with IHD in immunocompetent individuals is uncertain. METHODS We measured baseline CMV immunoglobulin G (IgG) levels in 12,574 participants without IHD from the population-based EPIC-Norfolk cohort, aged 40-70 years old at recruitment in 1993-1997. Underlying causes of death or hospitalization until 31 March 2008 were… CONTINUE READING
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