Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients.

  title={Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients.},
  author={Christina V. Obiezu and Andreas Scorilas and Dionyssios Katsaros and Marco Massobrio and George Makram Yousef and Stefano Fracchioli and Irene A Rigault de la Longrais and Riccardo Arisio and Eleftherios P Diamandis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={7 8},
PURPOSE Kallikrein gene 4 (KLK4, also known as prostase/KLK-L1), located on chromosome 19q13.4, is one of the newly discovered members of the human KLK-like gene family. This gene is up-regulated by androgens in the LNCaP prostatic carcinoma cell line and by androgens and progestins in the BT-474 breast cancer cell line. On the basis of its apparent association with hormonally regulated tissues, we have undertaken to examine the prognostic value of KLK4 expression in 147 malignant ovarian… CONTINUE READING


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Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression

P. S. Nelson, L. Gan, C. Fergusson
Proc. Natl. Acad. Sci. USA, • 1999
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Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3–13.4

Stephenson, S-A, K. Verity, L. K. Ashworth, J. A. Clements
J. Biol. Chem., • 1999
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