Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats

@article{Sahm2018HigherGE,
  title={Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats},
  author={A. Sahm and Martin Bens and Y. Henning and Christiane Vole and M. Groth and M. Schwab and Steve Hoffmann and M. Platzer and K. Szafranski and P. Dammann},
  journal={Aging (Albany NY)},
  year={2018},
  volume={10},
  pages={3938 - 3956}
}
Many aging-associated physiological changes are known to occur in short- and long-lived species with different trajectories. Emerging evidence suggests that numerous life history trait differences between species are based on interspecies variations in gene expression. Little information is available, however, about differences in transcriptome changes during aging between mammals with diverging lifespans. For this reason, we studied the transcriptomes of five tissue types and two age cohorts… Expand
Alternative Animal Models of Aging Research
The Genetics of Aging: A Vertebrate Perspective

References

SHOWING 1-10 OF 25 REFERENCES
Slow aging in mammals-Lessons from African mole-rats and bats.
  • P. Dammann
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 2017
Gene expression defines natural changes in mammalian lifespan
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
...
1
2
3
...