Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis.

@article{Xiao2013HigherFO,
  title={Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitis.},
  author={Fei Xiao and Hai-Yu Zhang and Yijun Liu and Ding Zhao and Yu-xing Shan and Yan-fang Jiang},
  journal={The Journal of rheumatology},
  year={2013},
  volume={40 12},
  pages={2029-37}
}
OBJECTIVE The role of follicular Th (TFH) cells remains unclear in the pathogenesis of ankylosing spondylitis (AS). Our study examined the frequency of different subsets of circulating CXCR5+CD4+ T cells in patients with AS before and after receiving therapy. METHODS Percentages of peripheral blood inducible costimulator (ICOS)+, programmed death 1 (PD-1)+, and interleukin 21 (IL-21)+ CXCR5+CD4+ T cells in 26 patients with AS and 12 healthy controls (HC) were examined by flow cytometry, and… CONTINUE READING

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