Higher frequency of occult lymph node metastasis in clinical N0 pulmonary adenocarcinoma with ALK rearrangement

@inproceedings{Seto2018HigherFO,
  title={Higher frequency of occult lymph node metastasis in clinical N0 pulmonary adenocarcinoma with ALK rearrangement},
  author={Katsutoshi Seto and Hiroaki Mishima Kuroda and Tatsuya Marunouchi Chome Yoshida and Shozo Sakata and T Mizuno and Noriaki Sakakura and Toyoaki Hida and Yasushi Yatabe and Yukinori Sakao},
  booktitle={Cancer management and research},
  year={2018}
}
Objectives There have been few studies that have fully elucidated the relationship between genomic mutations in pulmonary adenocarcinomas and occult lymph node (LN) metastases (pN1-2) despite a preoperative clinical N0 stage (cN0). It is well known that anaplastic lymphoma kinase (ALK) rearrangements are more likely to occur in younger patients with high grade tumors. The aim of this study was to investigate the genomic status, examine the clinicopathologic features, and evaluate whether ALK… CONTINUE READING

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