Higher dopamine release induced by less rather than more preferred reward during a working memory task in the primate prefrontal cortex

@article{Kodama2014HigherDR,
  title={Higher dopamine release induced by less rather than more preferred reward during a working memory task in the primate prefrontal cortex},
  author={Tatsuhiko Kodama and Kazuo Hikosaka and Yoshiko Honda and Takashi Kojima and Masataka Watanabe},
  journal={Behavioural Brain Research},
  year={2014},
  volume={266},
  pages={104-107}
}
An optimal level of dopamine (DA) in the mammalian prefrontal cortex (PFC) is critical for higher cognitive control of behavior. Too much or too little DA in the PFC induces impairment in working memory (WM) task performance. PFC DA is also concerned with motivation. When reward is anticipated and/or delivered, an increase in PFC DA release is observed. In the primate, more preferred reward induces enhanced WM-related neuronal activity in the dorsolateral PFC (DLPFC). We hypothesized that there… CONTINUE READING
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