Higher concentrations of interferon-gamma enhances uptake and transport of dietary antigens by human intestinal cells: a study using cultured Caco-2 cells.

@article{Koda2003HigherCO,
  title={Higher concentrations of interferon-gamma enhances uptake and transport of dietary antigens by human intestinal cells: a study using cultured Caco-2 cells.},
  author={T. Koda and Hisanori Minami and Tadashi Ogawa and Mariko Yamano and Eiji Takeda},
  journal={Journal of nutritional science and vitaminology},
  year={2003},
  volume={49 3},
  pages={179-86}
}
Besides functioning as a mucosal barrier and transporting nutrients, intestinal epithelial cells (IECs) also serve as antigen-presenting cells (APCs). Modification of protein antigens by proteolysis is one of the principal steps in antigen presentation to Th cells. We used a Caco-2 intestinal epithelial cell line to investigate the transepithelial transport of the dietary antigen, ovalbumin (OVA). We also examined the effects of the proinflammatory cytokine interferon-gamma (IFN-gamma) on the… CONTINUE READING