Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.

@article{Lee2012HigherCS,
  title={Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.},
  author={Seung Hun Lee and Sun-Young Lee and Young Sun Lee and Beom-Jun Kim and Kyeong-Hye Lim and Eun Hee Cho and Sungwoo Kim and J. -M. Koh and Ghi Su Kim},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 8},
  pages={E1421-8}
}
CONTEXT Several in vivo and in vitro studies suggest that sphingosine-1-phosphate (S1P) is known to act as a coupling factor, to stimulate osteoclastogenesis, to control the migration of osteoclast precursors between the blood and bone, and to stimulate the proliferation, migration, and survival of osteoblasts. OBJECTIVE Using the determination of circulating S1P levels, we investigated which kinds of processes may be primarily affected by S1P in humans. DESIGN AND SETTING This was a cross… CONTINUE READING
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