Higher bypass temperature correlates with increased white cell activation in the cerebral microcirculation.

@article{Anttila2004HigherBT,
  title={Higher bypass temperature correlates with increased white cell activation in the cerebral microcirculation.},
  author={V. -J. Anttila and Ikuo Hagino and David Zurakowski and H G W Lidov and Richard A Jonas},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2004},
  volume={127 6},
  pages={1781-8}
}
OBJECTIVE Cardiopulmonary bypass induces a systemic inflammatory response, which in turn promotes a cascade of leukocyte and endothelial cell activity. We investigated whether differences in bypass temperature and flow rate affect endothelial cell and leukocyte adhesion in the cerebral microcirculation. METHODS Thirty-six piglets (13.0 +/- 1.1 kg) had a cranial window placed over the parietal cortex to evaluate the microcirculation by means of intravital microscopy. Animals were cooled to a… CONTINUE READING