Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes

@article{Fang2007HigherOrderOT,
  title={Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes },
  author={Yi Fang and Ning Wu and Xin Jun Gan and Wanhua Yan and James C. Morrell and Stephen J. Gould},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={63 - 70}
}
Exosomes are secreted organelles that have the same topology as the cell and bud outward (outward is defined as away from the cytoplasm) from endosome membranes or endosome-like domains of plasma membrane. Here we describe an exosomal protein-sorting pathway in Jurkat T cells that selects cargo proteins on the basis of both higher-order oligomerization (the oligomerization of oligomers) and plasma membrane association, acts on proteins seemingly without regard to their function, sequence… CONTINUE READING
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