Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

@article{FuenteSandoval2011HigherLO,
  title={Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis},
  author={Camilo de la Fuente-Sandoval and Pablo Le{\'o}n-Ort{\'i}z and Rafael Favila and Sylvana Stephano and David C. Mamo and Jes{\'u}s Ram{\'i}rez-Berm{\'u}dez and Ariel Graff-Guerrero},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1781-1791}
}
The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy (1H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects… CONTINUE READING
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