Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study

Abstract

The growth of myeloma cells depends on bone marrow (BM) stroma consisting of stromal cells, secreted cytokines and the extracellular matrix (ECM). Decorin, a small leucine-rich proteoglycan in the ECM, is a signaling ligand and native anti-tumor agent. However, the role of decorin in patients with myeloma is not clear. We evaluated the correlation between… (More)
DOI: 10.1371/journal.pone.0137552

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@inproceedings{Huang2015HigherDL, title={Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study}, author={Sheng-Yi Huang and Hsiu-Hsia Lin and Ming Yao and J L Tang and Shang-Ju Wu and Hsin-An Hou and W H Chou and Sheng-Chieh Chou and Szu-Chun Hsu and Bor-Sheng Ko and Hsiao-Yun Lu and Woei Tsay and H F Tien and Holger Werner Auner}, booktitle={PloS one}, year={2015} }