Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study.

@article{Dillon2017HigherCP,
  title={Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study.},
  author={Simon T. Dillon and Sarinnapha M. Vasunilashorn and Long H. Ngo and Hasan H. Otu and Sharon K. Inouye and Richard N. Jones and David C. Alsop and George A Kuchel and Eran D Metzger and Steven Edward Arnold and Edward R. Marcantonio and T. A. Libermann},
  journal={Biological psychiatry},
  year={2017},
  volume={81 2},
  pages={145-153}
}
BACKGROUND Delirium is a common, morbid, and costly postoperative complication. We aimed to identify blood-based postoperative delirium markers in a nested case-control study of older surgical patients using a proteomics approach followed by enzyme-linked immunosorbent assay (ELISA) validation. METHODS The Successful Aging after Elective Surgery study enrolled dementia-free adults ≥70 years old undergoing major scheduled noncardiac surgery (N = 566; 24% delirium). Plasma was collected at four… CONTINUE READING